20th anniversary's coming up in Japan soon, so something's gotta give in regards to that.
As for a Gen 1 remake, the only course I can see them do is some sort of remake on the home console (Wii U unless Nintendo gives up on it by then.). It would celebrate the anniversary in high regard AND give fans that home console RPG game at the same time. Yeah, they've said the games are best on handheld but like Snap 2, fans are never going to shut up about.
Mind you, with what the Delta Episode said about the timeline of the games (Go look it up if you want to be spoilt) perhaps they'll do something with that in regards to Kanto?
Or if not at the very least, give us a Pokemon version of Hyrule Historia to solve this timeline confusion.... XD